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VIDO Research Demonstrates Effectiveness of Needle Free
Dr. Phil Willson-Vaccine and Infectious Disease Organization
Farmscape for October 8, 2003 (Episode 1359)
A just completed pilot study shows needle free vaccination of piglets
to be as effective as vaccination using needles and with fewer complications.
The study was conducted by the Vaccine and Infectious Disease Organization
at the University of Saskatchewan.
Vaccine delivery using the Agro-jet, a device which uses a medium
pressure blast of carbon dioxide gas to administer vaccine, was
compared to delivery using a standard 20 gauge one inch hypodermic
Program Manager for Vaccine Development Dr. Phil Willson says two
groups of piglets were vaccinated at six and nine weeks of age.
Clip-Dr. Phil Willson-Vaccine and Infectious Disease Organization.
We had eight pigs that we immunized with each of these techniques,
either with a traditional needle or with the needle free Agro-jet,
and these were given a booster vaccination three weeks after the
primary just as the vaccine label indicates is the appropriate way
to use it.
We then challenged them by exposure to virulent Actinobacillus bacteria.
What we compared was whether or not these pigs had an equivalent
amount of immunity as measured by their serum as well as whether
they were protected from a disease exposure.
It turns out they were quite equivalent in terms of their response.
The blood response was quite similar.
Piglets that were vaccinated using the needle free technique, using
the Agro-jet, turned out to have slightly less disease after challenge.
Dr. Willson says, so far, scientists have learned you can get good
effective immunity using this needle free approach.
However, he says, while the needle free technique produced equivalent
immunity, it became obvious that not as much vaccine went into the
pig so future research will investigate the possibility of achieving
effective immunity with smaller doses.
For Farmscape.Ca, I'm Bruce Cochrane.
*Farmscape is a presentation of Sask Pork and Manitoba Pork Council